w3: a controllable brain injury model with a defined size for evaluation of tissue engineered products

brain injury has a multiple pathophysiology for which there is no definite treatment. in this regard, tissue engineering is one of the probable strategies for repair of damaged tissue. but creating a proper model for testing the engineered products faced some difficulties, specially, when we want to evaluate the effects of a product on the volume of injury. the current brain injury methods couldn’t provide defined brain tissue damage. we propose a new method to solve the problem. previously, we introduced a new method for harvesting subventricular tissue from adult rat brain using a modified semi-automatic biopsy needle. we showed that a defined volume of tissue harvested from a specific area of brain without any adverse effect on other regions. we suggest using this biopsy procedure for creating a brain injury model with a defined size. using this controllable biopsy method, we can test engineered products in a rat model of brain injury and assessed the volume of cavity after performing treatments in different groups.